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KMID : 0360319940260010113
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 1 p.113 ~ p.118
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Effect of Retinoic Acid on the Growth of Subcutaneously Injected C1300 Neuroblastoma and on the Survival of the Host A/J Mice
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Abstract
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Deficiency of vitamin A and/or its precursors has been associated with increased cancer risk in animals and humans. Therapeutic trials of vitamin A and related compounds(retinoids) have demonstrated activities in several cancerous and
precancerous
conditions. We measured the effects of a retinoic acid on the growth of subcutaneously injected C1300 neuroblastoma and on the survival of the host A/J mice. The fifty A/J mice were inoculated with 106 of C1300 neuroblastoma cell in the right
back.
They
were divided into five groups. One group received saline as a control. Two groups recieved 2mg/kg and 5mg/kg of retinoic acid . The other two groups recieved low dose(50mg/kg and 100mg/kg) cysclophosphamide. Tumor volume and survival were
assessed.
The
survivals were significantly increased(p<0.05) in three groups, mice recieved 5mg/kg of retinoic acid, 50mg/kg and 100mg/kg of cyclophosphamide. Tumor volumes of the mice treated with 5mg/kg of retinoic acid were significantly lower than the
control
group(p<0.05). Retinoic acid suppressed the growth of neuroblastoma, it increased the survival of the treated mice if adequate doses were used.
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KEYWORD
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